| Name | Tubeimoside I | ||
| PubChem CID | 6110917 | ||
| Molecular Weight | 1319.4g/mol | ||
| Formula | C₆₃H₉₈O₂₉ | ||
| SMILES | CC1C2C(C(C(O1)OC3C(C(COC3OC(=O)C45CCC(CC4C6=CCC7C(C6(CC5)C)(CCC8C7(CC(C(C8(C)CO)OC9C(C(C(C(O9)CO)O)O)OC1C(C(C(CO1)OC(=O)CC(CC(=O)O2)(C)O)O)O)O)C)C)(C)C)O)O)O)OC1C(C(C(CO1)O)O)O | ||
| InChI | 1S/C63H98O29/c1-26-46-47(88-51-43(76)38(71)30(67)22-81-51)45(78)53(84-26)90-48-39(72)31(68)23-82-54(48)92-56(79)63-15-13-57(2,3)17-28(63)27-9-10-35-59(5)18-29(66)50(60(6,25-65)34(59)11-12-62(35,8)61(27,7)14-16-63)91-55-49(42(75)40(73)32(21-64)86-55)89-52-44(77)41(74)33(24-83-52)85-36(69)19-58(4,80)20-37(70)87-46/h9,26,28-35,38-55,64-68,71-78,80H,10-25H2,1-8H3 | ||
| InChIKey | MCPFEAJYKIXPQF-UHFFFAOYSA-N | ||
| Structure | 
|
Download
2D
MOL
3D
MOL
|
|
| Chineses Pinyin | TuBeiMu | ||
| Use Part | Tuberoid | ||
| Habitat | HeNan, HeBei, ShanDong, ShanXi, Shaanxi, GanSu, YunNan, HeNan, ShanXi, ShanXi, HeBei | ||
| Flavor | Bitter | ||
| Meridian Tropism | Lung, Spleen | ||
| Species |
>Kingdom: Viridiplantae
-->Phylum: Streptophyta
-->Class: Equisetopsida
-->Order: Cucurbitales
-->Family: Cucurbitaceae
-->Genus: Bolbostemma
-->Species: Bolbostemma paniculatum
|
||
| Pair Name | Tubeimoside I, Temozolomide | |||
| Partner Name | Temozolomide | |||
| Disease Info | [ICD-11: 2A00] | Glioblastoma multiforme | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Phosphorylation | AKT1 | hsa207 |
| Down-regulation | Expression | EGFR | hsa1956 | |
| Down-regulation | Expression | MGMT | hsa4255 | |
| Down-regulation | Phosphorylation | MTOR | hsa2475 | |
| Down-regulation | Phosphorylation | NFKB1 | hsa4790 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| Down-regulation | Phosphorylation | PIK3CA | hsa5290 | |
| Down-regulation | Phosphorylation | RELA | hsa5970 | |
| Down-regulation | Phosphorylation | RHOBTB2 | hsa23221 | |
| In Vitro Model | U-118MG | Astrocytoma | Homo sapiens (Human) | CVCL_0633 |
| T98G | Glioblastoma | Homo sapiens (Human) | CVCL_0556 | |
| Result | We first demonstrated that synergistic effects of TBMS1 and TMZ induced apoptosis in GBM cells through reducing MGMT expression and inhibiting the EGFR induced PI3K/Akt/mTOR/NF-κB signaling pathway. This study provides a rationale for combined application of TMZ and TBMS1 as a potential chemotherapeutic treatment for MGMT+ GBM patients. | |||
| Pair Name | Tubeimoside I, TNF-related apoptosis inducing ligand | |||
| Partner Name | TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2A00-2F9Z] | Solid tumour or cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | CFLAR | hsa8837 |
| Down-regulation | Expression | STAMBPL1 | hsa57559 | |
| In Vitro Model | Caki-1 | Clear cell renal cell carcinoma | Homo sapiens (Human) | CVCL_0234 |
| A-549 | Lung adenocarcinoma | Homo sapiens (Human) | CVCL_0023 | |
| HeLa | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0030 | |
| HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 | |
| In Vivo Model | Male SCID mice were inoculated subcutaneously at the flank with HCT116 (5×10⁶) cells. | |||
| Result | Our study revealed that STAMBPL1 is essential for c-FLIP stabilization, and that STAMBPL1 depletion enhances TRAIL-mediated apoptosis via c-FLIP downregulation. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Tubeimoside-I sensitizes temozolomide-resistant glioblastoma cells to chemotherapy by reducing MGMT expression and suppressing EGFR induced PI3K/Akt/mTOR/NF-κB-mediated signaling pathway. Phytomedicine. 2022 May;99:154016. doi: 10.1016/j.phymed.2022.154016. | Click |
| 2 | Tubeimoside-1 Enhances TRAIL-Induced Apoptotic Cell Death through STAMBPL1-Mediated c-FLIP Downregulation. Int J Mol Sci. 2023 Jul 24;24(14):11840. doi: 10.3390/ijms241411840. | Click |
